tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate

Base Information

Chemical Name:tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate
CAS No.:862907-07-1
Molecular Formula:C₂₁H₂₀F₃NO₄
Molecular Weight:407.389
Hs Code.:

Synonyms:tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate

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Chemical Property of tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate

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Technology Process of tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate

There total 7 articles about tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 862907-27-5
3-tert-butoxycarbonyloxy-3-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 862907-07-1
tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; ethyl acetate; at 20 ℃; for 1h;
DOI:10.1021/ja0513077

Reference yield:

: 343-69-1
6-(Trifluoromethyl)-1H-indol-2,3-dione

: 862907-07-1
tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 1 h / 0 °C

1.2: 81 percent / tetrahydrofuran / 4 h / -20 - 20 °C

2.1: DMAP / CH₂Cl₂ / 20 °C

3.1: 63 percent / H₂ / Pd(OH)2/C / methanol; ethyl acetate / 1 h / 20 °C

With dmap; hydrogen; sodium hydride; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja0513077

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 862907-07-1
tert-butyl 6-(trifluoromethyl)-3-(2-methoxyphenyl)-2-oxoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 78 percent / 4 h / 80 °C

2.1: s-BuLi / cyclohexane; hexane; tetrahydrofuran / 3 h / -40 °C

2.2: 87 percent / cyclohexane; hexane; tetrahydrofuran / 1 h / -78 °C

3.1: 96 percent / aq. HCl / tetrahydrofuran / 6 h / Heating

4.1: NaH / tetrahydrofuran / 1 h / 0 °C

4.2: 81 percent / tetrahydrofuran / 4 h / -20 - 20 °C

5.1: DMAP / CH₂Cl₂ / 20 °C

6.1: 63 percent / H₂ / Pd(OH)2/C / methanol; ethyl acetate / 1 h / 20 °C

With hydrogenchloride; dmap; hydrogen; sec.-butyllithium; sodium hydride; palladium dihydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; cyclohexane; ethyl acetate;
DOI:10.1021/ja0513077