3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one

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Chemical Name:3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one
CAS No.:1613395-07-5
Molecular Formula:C₂₁H₁₈ClF₄N₅O
Molecular Weight:467.853
Hs Code.:

Synonyms:3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one

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Chemical Property of 3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one

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Technology Process of 3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one

There total 8 articles about 3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1613395-78-0
C₂₂H₂₂ClF₄N₅O₄S

: 1613395-07-5
3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one

Guidance literature:: C₂₂H₂₂ClF₄N₅O₄S; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

With potassium carbonate; 2-methyl-4-(trifluoromethyl)-1H-imidazole; In N,N-dimethyl-formamide; at 55 ℃; for 3h;

Reference yield:

: 1567126-75-3
5-iodo-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylic acid

: 1613395-07-5
3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve

2.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 7 h / 100 - 110 °C / Inert atmosphere

2.2: 100 °C

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

4.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 4 h / 20 °C

5.1: triethylamine / dichloromethane / 2 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

6.2: 3 h / 55 °C

With hydrogenchloride; potassium phosphate; diphenyl phosphoryl azide; trimethylaluminum; palladium diacetate; sodium hydride; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; toluene; mineral oil; 2.1: |Suzuki Coupling;

Reference yield:

: 138907-70-7
ethyl 5-amino-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1613395-07-5
3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[5-cyclopropyl-1-(3-fluorophenyl)-1H-pyrazol-4-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: diiodomethane; isopentyl nitrite / acetonitrile / 1 h / 20 - 50 °C

2.1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran

3.1: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve

4.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 7 h / 100 - 110 °C / Inert atmosphere

4.2: 100 °C

5.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

6.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 4 h / 20 °C

7.1: triethylamine / dichloromethane / 2 h / 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

8.2: 3 h / 55 °C

With hydrogenchloride; potassium phosphate; lithium hydroxide monohydrate; diiodomethane; diphenyl phosphoryl azide; water; trimethylaluminum; palladium diacetate; sodium hydride; triethylamine; tricyclohexylphosphine; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile; mineral oil; 4.1: |Suzuki Coupling;