Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate

Base Information

Chemical Name:Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate
CAS No.:1191414-11-5
Molecular Formula:C₃₂H₃₉N₃O₅
Molecular Weight:545.679
Hs Code.:

Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate

Synonyms:Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate

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Chemical Property of Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate

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Technology Process of Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate

There total 7 articles about Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1191412-55-1
2-(2-methylpropyl)-4H-1,3,4-oxadiazin-5(6H)-one

: 1191414-10-4
methyl 4-({[4-(bromomethyl)phenyl](cyclopentyl)acetyl}amino)-2,3-dihydro-1H-indene-2-carboxylate

: 1191414-11-5
Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 209225-00-3
4-nitro-2,3-dihydro-1H-indene-2-carboxylic acid

: 1191414-11-5
Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 0.17 h / -10 °C

1.2: 3 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 22 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

With thionyl chloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 888327-26-2
dimethyl 4-nitro-1,3-dihydro-2H-indene-2,2-dicarboxylate

: 1191414-11-5
Methyl 4-{[cyclopentyl(4-{[2-(2-methylpropyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]-methyl}phenyl)acetyl]amino}-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C

1.2: pH 1 / Reflux

2.1: thionyl chloride / 0.17 h / -10 °C

2.2: 3 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 22 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

With thionyl chloride; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;