diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate

Base Information

• Chemical Name: diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate
• CAS No.: 1310817-81-2
• Molecular Formula: C₁₆H₁₈ClNO₄
• Molecular Weight: 323.776
• Mol file: 1310817-81-2.mol

Synonyms:diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate

Chemical Property of diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate

There total 5 articles about diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-((aziridin-1-yl)(3-chlorophenyl)methylene)malonic acid diethyl ester (1310817-71-0) → diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate (1310817-81-2)

Guidance literature:

With sodium iodide; In acetone; at 20 ℃; for 22h; Inert atmosphere;

DOI:10.3762/bjoc.7.95

Reference yield:

diethyl 2-(chloro(3-chlorophenyl)methylene)malonate (1310817-63-0) → diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate (1310817-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 11 h / 0 - 20 °C

2: sodium iodide / acetone / 22 h / 20 °C / Inert atmosphere

With sodium iodide; In tetrahydrofuran; acetone;

DOI:10.3762/bjoc.7.95

Reference yield:

diethyl 2-(3-chlorobenzoyl)malonate (30010-83-4) → diethyl 5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole-4,4-dicarboxylate (1310817-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: tributyl-amine; trichlorophosphate / Reflux

2: tetrahydrofuran / 11 h / 0 - 20 °C

3: sodium iodide / acetone / 22 h / 20 °C / Inert atmosphere

With tributyl-amine; sodium iodide; trichlorophosphate; In tetrahydrofuran; acetone;

DOI:10.3762/bjoc.7.95

upstream raw materials:

diethyl 2-(3-chlorobenzoyl)malonate

diethyl 2-(chloro(3-chlorophenyl)methylene)malonate

2-((aziridin-1-yl)(3-chlorophenyl)methylene)malonic acid diethyl ester

m-Chlorobenzoyl chloride