(E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate

Base Information

• Chemical Name: (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate
• CAS No.: 1268705-28-7
• Molecular Formula: C₂₅H₂₈N₂O₅
• Molecular Weight: 436.508
• Mol file: 1268705-28-7.mol

Synonyms:(E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate

Chemical Property of (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate

There total 3 articles about (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(E)-ethyl 2-(4-(1-(hydroxyimino)propyl)-2-methylphenoxy)acetate (1268705-04-9) + (5-methyl-2-phenyl-4-oxazolyl)methyl chloride (103788-61-0) → (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate (1268705-28-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 18h;

DOI:10.1016/j.bmc.2010.12.023

Reference yield:

1-(4-hydroxy-3-methylphenyl)propan-1-one (940-04-5) → (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate (1268705-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; caesium carbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2010.12.023

Reference yield:

propionic acid o-toluyl ester (7497-88-3) → (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetate (1268705-28-7)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / 2 h / 25 - 165 °C

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

3: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1 h / Reflux

4: caesium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

With aluminum (III) chloride; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; caesium carbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2010.12.023

upstream raw materials:

(E)-ethyl 2-(4-(1-(hydroxyimino)propyl)-2-methylphenoxy)acetate

(5-methyl-2-phenyl-4-oxazolyl)methyl chloride

1-(4-hydroxy-3-methylphenyl)propan-1-one

propionic acid o-toluyl ester

Downstream raw materials:

(E)-2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)propyl)phenoxy)acetic acid