C₃₂H₄₃PS

Base Information

• Chemical Name: C₃₂H₄₃PS
• CAS No.: 1620886-33-0
• Molecular Formula: C₃₂H₄₃PS
• Molecular Weight: 490.733
• Mol file: 1620886-33-0.mol

Synonyms:C₃₂H₄₃PS

Chemical Property of C₃₂H₄₃PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₃₂H₄₃PS

There total 3 articles about C₃₂H₄₃PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Iodothiophene (3437-95-4,149762-92-5) + C28H41P (1620886-26-1) → C32H43PS (1620886-33-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In diethylamine; at 20 ℃; for 14h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201402406

Reference yield:

(Z)-2-bromo-1-(2,4,6-tri-t-butylphenyl)-1-phosphapropene (100281-28-5,100281-29-6,100281-32-1) → C32H43PS (1620886-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; ethyl bromide / tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux

1.2: Reflux

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / diethylamine / 14 h / 20 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethyl bromide; magnesium; triethylamine; In tetrahydrofuran; diethylamine; 2.1: |Sonogashira Cross-Coupling;

DOI:10.1002/chem.201402406

Reference yield:

[(dibromomethylene)(2,4,6-tri-tertbutylphenyl)phosphine] (100281-23-0) → C32H43PS (1620886-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; diethyl ether; pentane / 0.5 h / -120 °C / Inert atmosphere; Schlenk technique

1.2: 2.5 h / -120 - 20 °C / Inert atmosphere; Schlenk technique

2.1: magnesium; ethyl bromide / tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux

2.2: Reflux

3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / diethylamine / 14 h / 20 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethyl bromide; n-butyllithium; magnesium; triethylamine; In tetrahydrofuran; diethyl ether; diethylamine; pentane; 3.1: |Sonogashira Cross-Coupling;

DOI:10.1002/chem.201402406

upstream raw materials:

(Z)-2-bromo-1-(2,4,6-tri-t-butylphenyl)-1-phosphapropene

[(dibromomethylene)(2,4,6-tri-tertbutylphenyl)phosphine]

2-Iodothiophene

C₂₈H₄₁P

Downstream raw materials:

C₃₈H₄₈P₂S