Fumiquinazoline A

Base Information

Chemical Name:Fumiquinazoline A
CAS No.:140715-85-1
Molecular Formula:C₂₄H₂₃N₅O₄
Molecular Weight:445.478
Hs Code.:
ChEMBL ID:CHEMBL2229120
DSSTox Substance ID:DTXSID801017927
Metabolomics Workbench ID:63429,172116
Nikkaji Number:J679.784I
Wikidata:Q27133341

Synonyms:fumiquinazoline A

Suppliers and Price of Fumiquinazoline A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Fumiquinazoline A

Chemical Property:

PSA：0.00000
LogP:0.00000
XLogP3:0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:445.17500423
Heavy Atom Count:33
Complexity:923

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C2=NC3=CC=CC=C3C(=O)N2C(C(=O)N1)CC4(C5NC(C(=O)N5C6=CC=CC=C64)C)O
Isomeric SMILES:C[C@H]1C2=NC3=CC=CC=C3C(=O)N2[C@@H](C(=O)N1)C[C@]4([C@H]5N[C@H](C(=O)N5C6=CC=CC=C64)C)O

Technology Process of Fumiquinazoline A

There total 23 articles about Fumiquinazoline A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 316828-53-2
N-19-benzyloxycarbonyl-fumiquinazoline A

: 140715-85-1,140852-71-7
fumiquinazoline A

Guidance literature:: With hydrogen; 5percent Pd/C; In methanol; at 20 ℃; for 0.5h;
DOI:10.1021/jo0264980

Reference yield:

: 14907-27-8,5619-09-0,7524-52-9,26988-71-6,41222-70-2,67557-19-1,109492-62-8
(R)-(+)-tryptophan methyl ester hydrochloride

: 140715-85-1,140852-71-7
fumiquinazoline A

Guidance literature:: Multi-step reaction with 15 steps

1.1: 96 percent / NaHCO₃ / diethyl ether; H₂O / 4 h / 20 °C

2.1: 92 percent / BH₃*THF / tetrahydrofuran; trifluoroacetic acid / 1 h / 0 °C

3.1: DCC / CH₂Cl₂ / 0.33 h / 20 °C

4.1: 3.53 g / DDQ / toluene / 2 h / 110 °C

5.1: Hg(OTFA)2 / CH₂Cl₂ / 0.33 h / 20 °C

5.2: 85 percent / I₂ / CH₂Cl₂ / 3 h / 20 °C

6.1: 64 percent / P(o-tolyl)3; K₂CO₃ / Pd₂(dba)3 / toluene / 2 h / 105 °C

7.1: 65 percent / 7b-Bu-7bH-oxaziridino[2,3-b][1,2]benzisothiazole-3,3-dioxide / CH₂Cl₂ / 12 h / 20 °C

8.1: 9 percent / NaBH₄; AcOH / 2 h / 25 °C

9.1: Zn dust; AcOH / 0.5 h / 20 °C

10.1: 134 mg / EDAC / acetonitrile / 1.33 h / 20 °C

11.1: 89 percent / EDAC / acetonitrile / 1.5 h / 20 °C

12.1: 76 percent / PPh₃; Br₂; Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

13.1: ethyl acetate / 0.17 h / 20 °C

14.1: 38 mg / acetonitrile / 2 h / Heating

15.1: 90 percent / H₂ / 5percent Pd/C / methanol / 0.5 h / 20 °C

With sodium tetrahydroborate; borane-THF; 7b-Bu-7bH-oxaziridino[2,3-b][1,2]benzisothiazole-3,3-dioxide; hydrogen; bromine; mercury(II) trifluoroacetate; sodium hydrogencarbonate; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; toluene; acetonitrile; trifluoroacetic acid;
DOI:10.1021/jo0264980

Reference yield:

: 316828-30-5
N_α-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester

: 140715-85-1,140852-71-7
fumiquinazoline A

Guidance literature:: Multi-step reaction with 14 steps

1.1: 92 percent / BH₃*THF / tetrahydrofuran; trifluoroacetic acid / 1 h / 0 °C

2.1: DCC / CH₂Cl₂ / 0.33 h / 20 °C

3.1: 3.53 g / DDQ / toluene / 2 h / 110 °C

4.1: Hg(OTFA)2 / CH₂Cl₂ / 0.33 h / 20 °C

4.2: 85 percent / I₂ / CH₂Cl₂ / 3 h / 20 °C

5.1: 64 percent / P(o-tolyl)3; K₂CO₃ / Pd₂(dba)3 / toluene / 2 h / 105 °C

6.1: 65 percent / 7b-Bu-7bH-oxaziridino[2,3-b][1,2]benzisothiazole-3,3-dioxide / CH₂Cl₂ / 12 h / 20 °C

7.1: 9 percent / NaBH₄; AcOH / 2 h / 25 °C

8.1: Zn dust; AcOH / 0.5 h / 20 °C

9.1: 134 mg / EDAC / acetonitrile / 1.33 h / 20 °C

10.1: 89 percent / EDAC / acetonitrile / 1.5 h / 20 °C

11.1: 76 percent / PPh₃; Br₂; Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

12.1: ethyl acetate / 0.17 h / 20 °C

13.1: 38 mg / acetonitrile / 2 h / Heating

14.1: 90 percent / H₂ / 5percent Pd/C / methanol / 0.5 h / 20 °C

With sodium tetrahydroborate; borane-THF; 7b-Bu-7bH-oxaziridino[2,3-b][1,2]benzisothiazole-3,3-dioxide; hydrogen; bromine; mercury(II) trifluoroacetate; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene; acetonitrile; trifluoroacetic acid;
DOI:10.1021/jo0264980