6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

Base Information

Chemical Name:6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester
CAS No.:145709-20-2
Molecular Formula:C₃₄H₅₇N₃O₇S₂Si₂
Molecular Weight:740.145
Hs Code.:

6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

Synonyms:6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

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Chemical Property of 6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

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Technology Process of 6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

There total 4 articles about 6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 160517-46-4
1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<<5-<(tert-butyldimethylsilyl)oxy>pentyl>thio>-3-nitrophenyl>-5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

: 145709-20-2
6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: With dmap; In acetonitrile; for 2h; Ambient temperature;
DOI:10.1021/jm00001a017

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 145709-20-2
6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate / toluene / 90 °C

2: 82 percent / acetic acid, piperidine / benzene / 1 h / Heating

3: 88 percent / sodium acetate / dimethylformamide / 4 h / 75 °C

4: 67 percent / 4-(N,N-dimethylamino)pyridine / acetonitrile / 2 h / Ambient temperature

With piperidine; dmap; sodium acetate; acetic acid; In N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1021/jm00001a017

Reference yield:

: 17165-45-6
2-(trimethylsilyl)ethyl acetoacetate

: 145709-20-2
6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / acetic acid, piperidine / benzene / 1 h / Heating

2: 88 percent / sodium acetate / dimethylformamide / 4 h / 75 °C

3: 67 percent / 4-(N,N-dimethylamino)pyridine / acetonitrile / 2 h / Ambient temperature

With piperidine; dmap; sodium acetate; acetic acid; In N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm00001a017