2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride

Base Information

Chemical Name:2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride
CAS No.:1299467-02-9
Molecular Formula:C₂₃H₁₉F₃N₂O₃*ClH
Molecular Weight:464.872
Hs Code.:

Synonyms:2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride

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Chemical Property of 2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride

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Technology Process of 2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride

There total 5 articles about 2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1299467-03-0
2-[N'-tert-butoxycarbonyl-N'-(2-methoxy-ethyl)-hydrazino]-3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzoic acid methyl ester

: 1299467-02-9
2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; for 1.5h; Reflux;
DOI:10.1016/j.bmcl.2013.03.049

Reference yield:

: 1299597-19-5
2-(2-Methoxy-ethyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one

: 1299467-02-9
2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride

Guidance literature:: With hydrogenchloride;

Reference yield:

: 1298129-65-3
2',4',5'-trifluoro-biphenyl-4-ol

: 1299467-02-9
2-(2-methoxyethyl)-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,2-dihydroindazol-3-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: caesium carbonate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; palladium diacetate; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.049