N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide

Base Information

• Chemical Name: N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide
• CAS No.: 135734-45-1
• Molecular Formula: C₄₃H₆₉NO₄Si
• Molecular Weight: 692.111
• Mol file: 135734-45-1.mol

Synonyms:N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide

Chemical Property of N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide

There total 9 articles about N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,2-dimethylbutanoyl chloride (5856-77-9) + C-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexyl]-methylamine (136491-78-6) → N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide (135734-45-1)

Guidance literature:

With dmap; In pyridine;

DOI:10.1016/0040-4039(91)80587-V

Reference yield:

[(1S,2S,3S,6S)-6-Allyl-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-cyclohexyl]-methanol (135716-19-7) → N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide (135734-45-1)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / 10percent Pd-C / methanol

2: Et₃N / CH₂Cl₂ / 0 °C

3: NaN₃ / dimethylformamide / 50 °C

4: H₂, Et₃N / 10percent Pd-C / ethanol; methanol

5: 76 percent / DMAP / pyridine

With dmap; sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(91)80587-V

Reference yield:

[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexyl]-methanol (135716-23-3) → N-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexylmethyl]-2,2-dimethyl-butyramide (135734-45-1)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0 °C

2: NaN₃ / dimethylformamide / 50 °C

3: H₂, Et₃N / 10percent Pd-C / ethanol; methanol

4: 76 percent / DMAP / pyridine

With dmap; sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(91)80587-V

upstream raw materials:

2,2-dimethylbutanoyl chloride

C-[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexyl]-methylamine

[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexyl]-methanol

[(1S,2S,3S,6S)-6-Allyl-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-cyclohexyl]-methanol

Downstream raw materials:

N-{(1S,2S,3S,6R)-2-[2-((2R,4R)-4-Hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl}-2,2-dimethyl-butyramide

[(4R,6R)-6-(2-{(1S,2S,3R,6S)-2-[(2,2-Dimethyl-butyrylamino)-methyl]-6-methyl-3-propyl-cyclohexyl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetic acid

[(4R,6R)-6-(2-{(1S,2S,3R,6S)-2-[(2,2-Dimethyl-butyrylamino)-methyl]-6-methyl-3-propyl-cyclohexyl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetic acid methyl ester

[1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt