3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol

Base Information

• Chemical Name: 3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol
• CAS No.: 920509-24-6
• Molecular Formula: C₁₆H₁₇Br₂ClN₂O₂
• Molecular Weight: 464.584
• Mol file: 920509-24-6.mol

Synonyms:3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol

Chemical Property of 3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol

There total 3 articles about 3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

3,6-dichloro-4-isopropyl-1,2-dihydropyridazine (107228-51-3) → 3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol (920509-24-6)

Guidance literature:

2,6-dibromo-4-(3-hydroxypropyl)phenol; With potassium tert-butylate; In N,N-dimethyl acetamide; at 20 - 100 ℃; for 0.25h;

3,6-dichloro-4-isopropyl-1,2-dihydropyridazine; In N,N-dimethyl acetamide; at 140 ℃; for 24h;

Reference yield:

3,6-dichloro-4-isopropyl-1,2-dihydropyridazine (107228-51-3) + 2,6-dibromo-4-(3-hydroxypropyl)phenol (38972-02-0) → 3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol (920509-24-6)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl acetamide; at 20 - 135 ℃; for 24h;

DOI:10.1021/jm4019299

Reference yield:

3-(4-hydroxyphenyl)propan-1-ol (10210-17-0) → 3-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]propan-1-ol (920509-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / 20 °C

2: potassium tert-butylate / N,N-dimethyl acetamide / 24 h / 20 - 135 °C

With potassium tert-butylate; bromine; acetic acid; In N,N-dimethyl acetamide;

DOI:10.1021/jm4019299

upstream raw materials:

3,6-dichloro-4-isopropyl-1,2-dihydropyridazine

2,6-dibromo-4-(3-hydroxypropyl)phenol

3-(4-hydroxyphenyl)propan-1-ol

Downstream raw materials:

3-[3,5-dibromo-4-(6-chloro-5-isopropyl-pyridazin-3-yloxy)-phenyl]-propionic acid