3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol

Base Information

Chemical Name:3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol
CAS No.:1332523-82-6
Molecular Formula:C₁₆H₁₇BrF₃NO₅
Molecular Weight:440.214
Hs Code.:

Synonyms:3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol

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Chemical Property of 3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol

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Technology Process of 3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol

There total 6 articles about 3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1332523-81-5
N-[2-(5-bromo-6-iodo-2,3,4-trimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

: 107-19-7
propargyl alcohol

: 1332523-82-6
3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; for 18h; chemoselective reaction; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.05.125

Reference yield:

: 1332523-80-4
N-[2-(5-bromo-2,3,4-trimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

: 1332523-82-6
3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 24 h / Inert atmosphere; Reflux

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 18 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; diethylamine; trifluoroacetic acid; In acetonitrile; 2: Sonogashira coupling;
DOI:10.1016/j.tet.2011.05.125

Reference yield:

: 1332523-79-1
N-[2-(2,3,4-trimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

: 1332523-82-6
3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / tetrachloromethane / 16 h / 60 °C / Inert atmosphere

2: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 24 h / Inert atmosphere; Reflux

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 18 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; N-iodo-succinimide; copper(l) iodide; diethylamine; trifluoroacetic acid; In tetrachloromethane; acetonitrile; 3: Sonogashira coupling;
DOI:10.1016/j.tet.2011.05.125