(2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine

Base Information

• Chemical Name: (2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine
• CAS No.: 344799-39-9
• Molecular Formula: C₂₇H₂₈N₂O₂
• Molecular Weight: 412.532
• Mol file: 344799-39-9.mol

Synonyms:(2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine

Chemical Property of (2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine

There total 3 articles about (2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-Phenylpropane-1,2-dione (579-07-7) + (1R,1'R)-N,N'-bis[(2-hydroxy-1-phenyl)ethyl]ethylenediamine (344799-36-6) → (2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine (344799-39-9)

Guidance literature:

In benzene; for 24h; Heating;

DOI:10.1016/S0957-4166(01)00036-2

Reference yield:

D-2-phenylglycinol (56613-80-0) → (2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine (344799-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / ethanol; H₂O / 3 h / Heating

2: 97 percent / BH₃-THF / tetrahydrofuran / 5 h / Heating

3: 70 percent / benzene / 24 h / Heating

With borane-THF; In tetrahydrofuran; ethanol; water; benzene;

DOI:10.1016/S0957-4166(01)00036-2

Reference yield:

(3R,7R,4aR,8aR)-perhydro[1,4]oxazino[3,2-b]-1,4-oxazine (344799-35-5) → (2R,2'S,4R,4'R)-N,N'-ethylene-(2'-methyl-2,4,4'-triphenyl)-2,2-bisoxazolidine (344799-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / BH₃-THF / tetrahydrofuran / 5 h / Heating

2: 70 percent / benzene / 24 h / Heating

With borane-THF; In tetrahydrofuran; benzene;

DOI:10.1016/S0957-4166(01)00036-2

upstream raw materials:

1-Phenylpropane-1,2-dione

(1R,1'R)-N,N'-bis[(2-hydroxy-1-phenyl)ethyl]ethylenediamine

D-2-phenylglycinol

(3R,7R,4aR,8aR)-perhydro[1,4]oxazino[3,2-b]-1,4-oxazine