(2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

Base Information

Chemical Name:(2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde
CAS No.:217820-14-9
Molecular Formula:C₂₀H₃₀O₆Si
Molecular Weight:394.54
Hs Code.:

Synonyms:(2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

Suppliers and Price of (2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

There total 1 articles about (2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: <2-<<<(2S,4aS,7S,7aR)-5-ethoxydihydro-7-(iodomethyl)-2-(p-methoxyphenyl)-4H-furo<3,4-d>-m-dioxin-4a(5H)-yl>oxy>methoxy>ethyl>trimethylsilane

: 217820-14-9
(2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

Guidance literature:: With pyridine; zinc; In ethanol; at 80 - 90 ℃; for 5h;
DOI:10.1021/jo981749j

Reference yield:

: 217820-14-9
(2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

: (1S,2R,4S,5S,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-[(2S,4R,5S)-4-(1-hydroxy-ethyl)-2-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]dioxan-5-yl]-2-methoxymethoxy-4,11,11-trimethyl-bicyclo[6.2.1]undecan-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium hexamethyldisilazide / 1.) THF, room temperature, 10 min, 2.) THF

2: 1.) n-butyllithium / 1.) ether, pentane, 5 min, 2.) ether, pentane, 20 min

3: 1.) 18-crown-6, potassium hexamethyldisilazide / 1.) THF, toluene, -78 -> -30 deg C, 2.) THF, toluene, 2 h

4: 41 percent / pyridine, osmium tetraoxide / 2 h

5: 73 percent / imidazole, 4-(N,N-dimethylamino)pyridine / dimethylformamide / Ambient temperature

6: 1.) thexylborane, 2.) KOH, H₂O₂ / 1.) THF, 0 deg C, 30 min, 2.) water, THF, 12 h

With pyridine; 1H-imidazole; dmap; potassium hydroxide; osmium(VIII) oxide; n-butyllithium; 18-crown-6 ether; thexylborane; dihydrogen peroxide; sodium hexamethyldisilazane; potassium hexamethylsilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jo981749j

Reference yield:

: 217820-14-9
(2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

: 217820-22-9
[(2S,4R,5S)-5-[(1S,2S,4S,5S,7R,8S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-7-methoxymethoxy-5,11,11-trimethyl-6-oxo-bicyclo[6.2.1]undec-4-yl]-2-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]dioxan-4-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) sodium hexamethyldisilazide / 1.) THF, room temperature, 10 min, 2.) THF

2: 1.) n-butyllithium / 1.) ether, pentane, 5 min, 2.) ether, pentane, 20 min

3: 1.) 18-crown-6, potassium hexamethyldisilazide / 1.) THF, toluene, -78 -> -30 deg C, 2.) THF, toluene, 2 h

4: 41 percent / pyridine, osmium tetraoxide / 2 h

5: 73 percent / imidazole, 4-(N,N-dimethylamino)pyridine / dimethylformamide / Ambient temperature

6: 1.) thexylborane, 2.) KOH, H₂O₂ / 1.) THF, 0 deg C, 30 min, 2.) water, THF, 12 h

7: 82 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h

With pyridine; 1H-imidazole; dmap; potassium hydroxide; osmium(VIII) oxide; n-butyllithium; 18-crown-6 ether; thexylborane; dihydrogen peroxide; sodium hexamethyldisilazane; potassium hexamethylsilazane; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981749j