(R)-N-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide
CAS No.:1268240-92-1
Molecular Formula:C₁₇H₂₇NO₃S
Molecular Weight:325.472
Hs Code.:

Synonyms:(R)-N-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

There total 2 articles about (R)-N-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1268240-76-1
(R_S,E)-N-[(2S)-2,3-(isopropylidenedioxy)propylidene]-2-methyl-2-propanesulfinamide

: 100-44-7
benzyl chloride

: 1268240-94-3
(R)-N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

: 1268240-92-1
(R)-N-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: benzyl chloride; With magnesium; lithium chloride; zinc(II) chloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Water bath;

(R_S,E)-N-[(2S)-2,3-(isopropylidenedioxy)propylidene]-2-methyl-2-propanesulfinamide; In tetrahydrofuran; at 20 ℃; for 24h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol103002t

Reference yield:

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 1268240-94-3
(R)-N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

: 1268240-92-1
(R)-N-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium (IV) ethoxide / dichloromethane / 6 h / Inert atmosphere

2.1: magnesium; lithium chloride; zinc(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere; Water bath

2.2: 24 h / 20 °C / Inert atmosphere

With titanium (IV) ethoxide; magnesium; lithium chloride; zinc(II) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol103002t