3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Base Information

Chemical Name:3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil
CAS No.:1296176-94-7
Molecular Formula:C₂₀H₁₅ClFN₃O₇
Molecular Weight:463.806
Hs Code.:

Synonyms:3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Suppliers and Price of 3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

There total 3 articles about 3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103766-30-9
2,4-bis(trimethylsilyloxy)-5-chloropyridine

: 3-(3-Ethoxymethyl-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbonyl)-benzoyl chloride

: 1296176-93-6
3-{3-[4-hydroxy-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

: 1296176-94-7
3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Guidance literature:: tin(IV) chloride; In dichloromethane; at 20 ℃; for 15h; Cooling with ice;

Reference yield:

: 129971-17-1
1-ethoxymethyl-3-m-hydroxycarbonylbenzoyl-5-fluorouracil

: 1296176-94-7
3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

2: tin(IV) chloride / dichloromethane / 15 h / 20 °C / Cooling with ice

With thionyl chloride; tin(IV) chloride; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 103766-25-2
5-Chloro-2,4-dihydroxypyridine

: 1296176-94-7
3-{3-[2-hydroxy-5-chloro-4-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 6 h / Reflux

2: tin(IV) chloride / dichloromethane / 15 h / 20 °C / Cooling with ice

tin(IV) chloride; In dichloromethane;