(1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde

Base Information

• Chemical Name: (1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde
• CAS No.: 1646293-99-3
• Molecular Formula: C₁₉H₂₅NO₄
• Molecular Weight: 331.412

Synonyms:(1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde

Chemical Property of (1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde

Chemical Property:

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Technology Process of (1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde

There total 2 articles about (1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-1-nitrohex-1-ene (49746-23-8,85149-02-6,85150-65-8) + (5E)-7-oxo-7-phenyl-hept-5-enal (169892-12-0) → (1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde (1646293-99-3)

Guidance literature:

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)thiourea; L-proline; In toluene; at 20 ℃; for 1h; diastereoselective reaction;

DOI:10.1002/anie.201404072

Reference yield:

(E)-1-nitrohex-1-ene (49746-23-8,85149-02-6,85150-65-8) + (5E)-7-oxo-7-phenyl-hept-5-enal (169892-12-0) → (1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde (1646293-99-3) + (1R,2R,3R,4S)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde (1646294-00-9)

Guidance literature:

With QD-4; L-proline; In toluene; at 20 ℃; for 1h; Overall yield = 92 %; Overall yield = 61.2 mg; diastereoselective reaction;

DOI:10.1002/anie.201404072

Reference yield:

(1R,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde (1646293-99-3) → C19H27NO4 (1646294-63-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; dichloromethane; at -78 ℃; for 2h;

DOI:10.1002/anie.201404072

upstream raw materials:

(E)-1-nitrohex-1-ene

(5E)-7-oxo-7-phenyl-hept-5-enal

Downstream raw materials:

C₁₉H₂₇NO₄

C₂₃H₃₁NO₅

(1S,2R,3R,4R)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexanecarbaldehyde

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