N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine
CAS No.:334976-41-9
Molecular Formula:C₂₉H₄₃NO₅Si
Molecular Weight:513.75
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine

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Technology Process of N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine

There total 2 articles about N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(tert-butyldiphenylsilyl)oxy-2-[(hydroxy)methyl]hexahydroisoxazolo[2,3-a]pyridine

: 334976-41-9
N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / PdCl₂ / methanol / 12 h / 20 °C

2: Et₃N / CH₂Cl₂ / 10 h / 20 °C

With hydrogen; triethylamine; palladium dichloride; In methanol; dichloromethane;
DOI:10.1021/ol015655z

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 3-[3-(tert-butyl-diphenyl-silanyloxy)-piperidin-2-yl]-propane-1,2-diol

: 334976-41-9
N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1021/ol015655z

Reference yield: 92.0%

: 334976-41-9
N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine

: 334976-42-0
N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-[(oxiranyl)methyl]piperidine

Guidance literature:: N-(tert-butoxycarbonyl)-3-(tert-butyldiphenylsilyl)oxy-2-(2,3-dihydroxypropyl)piperidine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With N-tosylimidazole; In tetrahydrofuran; at 20 ℃; for 12h; Further stages.;
DOI:10.1021/ol015655z