C₁₂H₂₁N₃O₃P^(1-)*Na⁽¹⁺⁾

Base Information

• Chemical Name: C₁₂H₂₁N₃O₃P^(1-)*Na⁽¹⁺⁾
• CAS No.: 76308-23-1
• Molecular Formula: C₁₂H₂₁N₃O₃P*Na
• Molecular Weight: 309.281
• Mol file: 76308-23-1.mol

Synonyms:C₁₂H₂₁N₃O₃P^(1-)*Na⁽¹⁺⁾

Chemical Property of C₁₂H₂₁N₃O₃P^(1-)*Na⁽¹⁺⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₂₁N₃O₃P^(1-)*Na⁽¹⁺⁾

There total 7 articles about C₁₂H₂₁N₃O₃P^(1-)*Na⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-diethylenimidophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester (76308-21-9) → C12H21N3O3P(1-)*Na(1+) (76308-23-1)

Guidance literature:

With sodium methylate; In methanol; water; at 20 ℃;

DOI:10.1007/BF00951237

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → C12H21N3O3P(1-)*Na(1+) (76308-23-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaOH, H₂, 2.) HCl (conc.) / 1.) Raney Ni / 1.) H₂O, 130 deg C, 150 atm, 8 h

2: 11.4 g / pyridine / 5 h / Heating

3: 86 percent / HCl (gas) / 2 h / Heating

4: 83 percent / POCl₃, Et₃N / diethyl ether

5: 60 percent / Et₃N / diethyl ether; CH₂Cl₂

6: 80 percent / MeONa / methanol; H₂O / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen; sodium methylate; triethylamine; trichlorophosphate; nickel; In methanol; diethyl ether; dichloromethane; water;

DOI:10.1007/BF00951237

Reference yield:

(cis-4-amino-cyclohexyl)-acetic acid (2952-01-4) → C12H21N3O3P(1-)*Na(1+) (76308-23-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 11.4 g / pyridine / 5 h / Heating

2: 86 percent / HCl (gas) / 2 h / Heating

3: 83 percent / POCl₃, Et₃N / diethyl ether

4: 60 percent / Et₃N / diethyl ether; CH₂Cl₂

5: 80 percent / MeONa / methanol; H₂O / 20 °C

With pyridine; hydrogenchloride; sodium methylate; triethylamine; trichlorophosphate; In methanol; diethyl ether; dichloromethane; water;

DOI:10.1007/BF00951237

upstream raw materials:

N-diethylenimidophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester

4-nitrobenzeneacetic acid

(cis-4-amino-cyclohexyl)-acetic acid

cis-4-aminocyclohexylacetic acid hydrochloride