Technology Process of 2-(2,3,4,5-tetrafluoro-6-(thiophen-3-yl)phenyl)-4,5-dihydrooxazole
There total 3 articles about 2-(2,3,4,5-tetrafluoro-6-(thiophen-3-yl)phenyl)-4,5-dihydrooxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,1'-bis-(diphenylphosphino)ferrocene; dichloro bis(acetonitrile) palladium(II); caesium carbonate;
In
monoethylene glycol diethyl ether;
at 130 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jo2023262
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0 - 20 °C / Inert atmosphere
2: 1,1'-bis-(diphenylphosphino)ferrocene; dichloro bis(acetonitrile) palladium(II); caesium carbonate / monoethylene glycol diethyl ether / 3 h / 130 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; dichloro bis(acetonitrile) palladium(II); caesium carbonate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane; monoethylene glycol diethyl ether;
2: Suzuki-Miyaura coupling reaction;
DOI:10.1021/jo2023262
- Guidance literature:
-
Multi-step reaction with 3 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 0 - 20 °C
2: triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0 - 20 °C / Inert atmosphere
3: 1,1'-bis-(diphenylphosphino)ferrocene; dichloro bis(acetonitrile) palladium(II); caesium carbonate / monoethylene glycol diethyl ether / 3 h / 130 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; dichloro bis(acetonitrile) palladium(II); benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane; monoethylene glycol diethyl ether;
3: Suzuki-Miyaura coupling reaction;
DOI:10.1021/jo2023262
