benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

Base Information

• Chemical Name: benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-
• CAS No.: 153805-33-5
• Molecular Formula: C₁₈H₂₄N₂O₃S₂
• Molecular Weight: 380.532
• Mol file: 153805-33-5.mol

Synonyms:benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

Chemical Property of benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

There total 3 articles about benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-<5-(methylsulfonyl)pentyl>-, <3aS-(3aα,4β,6aα)>- (146395-18-8) + Methyl thiosalicylate (4892-02-8) → benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- (153805-33-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jm00028a013

Reference yield:

biotin N-Hydroxysuccinimide ester (35013-72-0) → benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- (153805-33-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / NaBH₄ / hexamethylphosphoric acid triamide; tetrahydrofuran / 4 h / Ambient temperature

2: 90 percent / pyridine; CH₂Cl₂ / 10 h / Ambient temperature

3: 90 percent / 1.) K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

With sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00028a013

Reference yield:

1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-(5-hydroxypentyl)-, <3aS-(3aα,4β,6aα)>- (53906-36-8) → benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- (153805-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / pyridine; CH₂Cl₂ / 10 h / Ambient temperature

2: 90 percent / 1.) K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

With potassium carbonate; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00028a013

upstream raw materials:

1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-<5-(methylsulfonyl)pentyl>-, <3aS-(3aα,4β,6aα)>-

Methyl thiosalicylate

biotin N-Hydroxysuccinimide ester

1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-(5-hydroxypentyl)-, <3aS-(3aα,4β,6aα)>-

Downstream raw materials:

benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-