methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate

Base Information

Chemical Name:methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate
CAS No.:134163-29-4
Molecular Formula:C₂₀H₂₈ClN₃O₄S
Molecular Weight:441.979
Hs Code.:

Synonyms:methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate

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Chemical Property of methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate

Chemical Property:

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Technology Process of methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate

There total 7 articles about methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-32-4
1H-imidazole

: 134163-35-2
methyl 8-(p-chlorophenylsulfonamido)-4-(2-methylsulfonyloxyethyl)-octanoate

: 134163-29-4
methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 8h; Yield given;
DOI:10.1021/jm00101a015

Reference yield:

: 134163-31-8
4-(4-hydroxybutyl)-ε-caprolactone

: 134163-29-4
methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 1 h

2: 92 percent / NaN₃ / dimethylformamide / 18 h

3: 100 percent / Ph₃P, H₂O / tetrahydrofuran / 18 h / Ambient temperature

4: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h

5: 1N aq. NaOH / methanol / 18 h

6: SOCl₂ / 2.5 h

7: Et₃N / CH₂Cl₂ / 1 h / 0 °C

8: dimethylformamide / 8 h / 100 °C

With dmap; sodium hydroxide; thionyl chloride; sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00101a015

Reference yield:

: 134164-08-2
5-(4-Azido-butyl)-oxepan-2-one

: 134163-29-4
methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / Ph₃P, H₂O / tetrahydrofuran / 18 h / Ambient temperature

2: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h

3: 1N aq. NaOH / methanol / 18 h

4: SOCl₂ / 2.5 h

5: Et₃N / CH₂Cl₂ / 1 h / 0 °C

6: dimethylformamide / 8 h / 100 °C

With dmap; sodium hydroxide; thionyl chloride; water; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00101a015