5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde

Base Information

• Chemical Name: 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde
• CAS No.: 1609540-85-3
• Molecular Formula: C₁₄H₂₁FO₂Si
• Molecular Weight: 268.403
• Mol file: 1609540-85-3.mol

Synonyms:5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde

Chemical Property of 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde

There total 6 articles about 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

((3-bromo-4-fluorobenzyl)oxy)(tert-butyl)dimethylsilane (655237-57-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde (1609540-85-3)

Guidance literature:

((3-bromo-4-fluorobenzyl)oxy)(tert-butyl)dimethylsilane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1055/s-0033-1340069

Reference yield: 77.0%

1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene (113984-76-2) → 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde (1609540-85-3)

Guidance literature:

1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield: 77.0%

1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene (113984-76-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde (1609540-85-3)

Guidance literature:

1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmcl.2018.03.082

upstream raw materials:

3-bromo-4-fluoro-benzyl alcohol

3-bromo-4-fluorobenzoic acid

((3-bromo-4-fluorobenzyl)oxy)(tert-butyl)dimethylsilane

N,N-dimethyl-formamide