Technology Process of 4-(2-(phenylethynyl)phenyl)pent-1-en-3-on
There total 7 articles about 4-(2-(phenylethynyl)phenyl)pent-1-en-3-on which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; Dess-Martin periodane;
In
dichloromethane;
at 0 - 20 ℃;
for 0.5h;
DOI:10.1021/jo500561z
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Dess-Martin periodane
2.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / 20 °C
2.2: 24 h / 20 °C
3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C
3.2: 3 h / -78 - 0 °C
4.1: hydrogenchloride / tetrahydrofuran; water / 65 °C
5.1: tetrahydrofuran / 0.5 h / 0 °C
6.1: Dess-Martin periodane; pyridine / dichloromethane / 0.5 h / 0 - 20 °C
With
pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine;
In
tetrahydrofuran; dichloromethane; water; toluene;
2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling / 3.1: |Wittig Olefination / 3.2: |Wittig Olefination / 5.1: |Grignard Reaction;
DOI:10.1021/jo500561z
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / 20 °C
1.2: 24 h / 20 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C
2.2: 3 h / -78 - 0 °C
3.1: hydrogenchloride / tetrahydrofuran; water / 65 °C
4.1: tetrahydrofuran / 0.5 h / 0 °C
5.1: Dess-Martin periodane; pyridine / dichloromethane / 0.5 h / 0 - 20 °C
With
pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine;
In
tetrahydrofuran; dichloromethane; water; toluene;
1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling / 2.1: |Wittig Olefination / 2.2: |Wittig Olefination / 4.1: |Grignard Reaction;
DOI:10.1021/jo500561z
