[3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde

Base Information

Chemical Name:[3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde
CAS No.:948591-56-8
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:[3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde

Suppliers and Price of [3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde

There total 6 articles about [3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 948591-50-2
6-[3-(allyloxy)benzyl]-1-ethoxymethyl-5-ethyl-1H-pyrimidine-2,4-dione

: 948591-56-8
[3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde

Guidance literature:: 6-[3-(allyloxy)benzyl]-1-ethoxymethyl-5-ethyl-1H-pyrimidine-2,4-dione; With ozone; In dichloromethane; at -78 ℃; for 0.0416667h;

With oxygen; In dichloromethane; at -78 ℃;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃;
DOI:10.1007/s00706-006-0548-3

Reference yield:

: 948591-40-0
1-allyloxy-3-cyanomethylbenzene

: 948591-56-8
[3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 55 percent / activated Zn / tetrahydrofuran / 5 h / Heating

2.1: 41 percent / NaOEt / ethanol / 5 h / Heating

3.1: 91 percent / aq. chloroacetic acid / Heating

4.1: N,O-bis(trimethylsilyl)acetamide / CHCl₃ / 0.17 h

4.2: 53 percent / CHCl₃ / 20 °C

5.1: O₃ / CH₂Cl₂ / 0.04 h / -78 °C

5.2: O₂ / CH₂Cl₂ / -78 °C

5.3: 28 percent / dimethyl sulfide / CH₂Cl₂ / -78 - 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; sodium ethanolate; ozone; chloroacetic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1007/s00706-006-0548-3

Reference yield:

: 948591-42-2
ethyl 2-ethyl-3-oxo-4-[3-(allyloxy)phenyl]butyrate

: 948591-56-8
[3-(3-ethoxymethyl-5-ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylmethyl)phenoxy]acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 41 percent / NaOEt / ethanol / 5 h / Heating

2.1: 91 percent / aq. chloroacetic acid / Heating

3.1: N,O-bis(trimethylsilyl)acetamide / CHCl₃ / 0.17 h

3.2: 53 percent / CHCl₃ / 20 °C

4.1: O₃ / CH₂Cl₂ / 0.04 h / -78 °C

4.2: O₂ / CH₂Cl₂ / -78 °C

4.3: 28 percent / dimethyl sulfide / CH₂Cl₂ / -78 - 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; sodium ethanolate; ozone; chloroacetic acid; In ethanol; dichloromethane; chloroform;
DOI:10.1007/s00706-006-0548-3