(3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

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Chemical Name:(3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate
CAS No.:140677-50-5
Molecular Formula:C₂₄H₃₁N₃O₅
Molecular Weight:441.527
Hs Code.:

Synonyms:(3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

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Chemical Property of (3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

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Technology Process of (3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

There total 9 articles about (3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 88767-98-0,138333-09-2
ethyl (R)-4-phenyl-2-<<(trifluoromethyl)sulfonyl>oxy>butyrate

: 140677-49-2
(S)-ethyl 3-amino-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

: 140677-50-5
(3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

Guidance literature:: With triethylamine; In dichloromethane; for 1h; Heating;
DOI:10.1021/jo00039a007

Reference yield: 23.0%

: 82586-61-6
ethyl 2-bromo-4-phenylbutanoate

: 140677-49-2
(S)-ethyl 3-amino-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

: 140677-51-6
(3S,1'R)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

: 140677-50-5
(3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

Guidance literature:: With triethylamine; potassium iodide; In acetonitrile; Heating;
DOI:10.1021/jo00039a007

Reference yield:

: 140677-44-7
(S)-3-(benzyloxycarbonyl)-4-(6,6-(ethylenedioxy)-3-oxohexyl)oxazolidin-5-one

: 140677-50-5
(3S,1'S)-ethyl-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 12 percent / NaOAc / methanol / 0.5 h / 50 °C

2: 66 percent / 20percent HCl / tetrahydrofuran / 0.25 h / 50 °C

3: 89 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature

4: 23 percent / NEt₃, KI / acetonitrile / Heating

With hydrogenchloride; hydrogen; sodium acetate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetonitrile;
DOI:10.1021/jo00039a007