2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane

Base Information

Chemical Name:2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane
CAS No.:116399-89-4
Molecular Formula:C₁₆H₂₈O₃
Molecular Weight:268.397
Hs Code.:

Synonyms:2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane

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Chemical Property of 2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane

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Technology Process of 2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane

There total 7 articles about 2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88154-77-2
(5R)-5-methyl-2-(phenylsulfinyl)cyclohexan-1-one

: 116399-89-4
2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, HMPA / 1.) THF, -78 deg C

2: Al(Hg) / tetrahydrofuran; H₂O

With N,N,N,N,N,N-hexamethylphosphoric triamide; aluminum amalgam; lithium diisopropyl amide; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)96582-1

Reference yield:

: 308358-04-5,5730-01-8
(6R)-2,2,6-trimethyl-1-oxaspiro[2.5]octan-4-one

: 116399-89-4
2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, reflux, 24 h

2: 95 percent / m-CPBA / CH₂Cl₂ / -78 °C

3: 1.) LDA, HMPT / 1.) THF, hexane, -35 deg C, 3 h, 2.) THF, hexane, from -35 deg C to RT, 2 h

4: Al, H₂O, 2percent mercuric chloride / tetrahydrofuran / 2 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; water; sodium hydride; 3-chloro-benzenecarboperoxoic acid; aluminium; mercury dichloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00029a028

Reference yield:

: 101693-93-0
(5R)-5-methyl-2-(phenylthio)cyclohexan-1-one

: 116399-89-4
2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / m-CPBA / CH₂Cl₂ / -78 °C

2: 1.) LDA, HMPT / 1.) THF, hexane, -35 deg C, 3 h, 2.) THF, hexane, from -35 deg C to RT, 2 h

3: Al, H₂O, 2percent mercuric chloride / tetrahydrofuran / 2 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; water; 3-chloro-benzenecarboperoxoic acid; aluminium; mercury dichloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00029a028