(S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester
CAS No.:1370417-03-0
Molecular Formula:C₂₀H₂₃NO₄
Molecular Weight:341.407
Hs Code.:

Synonyms:(S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester

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Chemical Property of (S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester

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Technology Process of (S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester

There total 1 articles about (S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 42288-46-0
(3,5-dimethylphenyl)acetic acid

: 3417-91-2
L-tyrosine methyl ester HCl

: 1370417-03-0
(S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester

Guidance literature:: (3,5-dimethylphenyl)acetic acid; With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

L-tyrosine methyl ester HCl; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield: 97.0%

: 1370417-03-0
(S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester

: 1276021-02-3
(S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid

Guidance literature:: (S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester; With sodium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 1370417-03-0
(S)-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanoic acid methyl ester

: 1276020-69-9
(S)-N-[4-(imidazo[2,1-b]benzothiazol-2-yl)phenyl]-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 1 h / 20 °C

1.2: pH 2

2.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2011.10.051