N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide

Base Information

• Chemical Name: N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide
• CAS No.: 813426-35-6
• Molecular Formula: C₃₄H₃₀N₂O₃
• Molecular Weight: 514.624

Synonyms:N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide

Chemical Property of N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide

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Technology Process of N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide

There total 1 articles about N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1,2,3,5-tetrahydrospiro[4H-1-benzazepine-4,1'-cyclopentan]-2'-one (813426-37-8) + 4-[([1,1'-biphenyl]-2-carbonyl)amino]-benzoyl chloride (180340-05-0) → N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide (813426-35-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 98.0%

N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide (813426-35-6) → N-[4-[(2,3-dihydro-2'-(hydroxyimino)spiro[4H-1-benzazepine-4,1'-cyclopentan]-1(5H)-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide (1014990-68-1)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 5h; Heating / reflux;

Reference yield:

N-[4-[(1,2,3,5-Tetrahydro-2'-oxospiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide (813426-35-6) → N-[4-[(1,2,3,5-Tetrahydro-2'-hydroxyspiro[4H-1-benzazepine-4,1'-cyclopentan]-1-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 24h;

upstream raw materials:

1,2,3,5-tetrahydrospiro[4H-1-benzazepine-4,1'-cyclopentan]-2'-one

4-[([1,1'-biphenyl]-2-carbonyl)amino]-benzoyl chloride

Downstream raw materials:

N-[4-[(2,3-dihydro-2'-(hydroxyimino)spiro[4H-1-benzazepine-4,1'-cyclopentan]-1(5H)-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide

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