tert-butyl {(1R,2S)-1-[(16S,19R)-15,18-dioxo-16-(propan-2-yl)-2,5,8,11-tetraoxa-14,17,20-triazabicyclo[20.2.2]hexacosa-1(24),22,25-trien-19-yl]-1-hydroxy-3-phenylpropan-2-yl}carbamate

Base Information

• Chemical Name: tert-butyl {(1R,2S)-1-[(16S,19R)-15,18-dioxo-16-(propan-2-yl)-2,5,8,11-tetraoxa-14,17,20-triazabicyclo[20.2.2]hexacosa-1(24),22,25-trien-19-yl]-1-hydroxy-3-phenylpropan-2-yl}carbamate
• CAS No.: 180968-37-0
• Molecular Formula: C36H54N4O9
• Molecular Weight: 686.8354

Synonyms:

Chemical Property of tert-butyl {(1R,2S)-1-[(16S,19R)-15,18-dioxo-16-(propan-2-yl)-2,5,8,11-tetraoxa-14,17,20-triazabicyclo[20.2.2]hexacosa-1(24),22,25-trien-19-yl]-1-hydroxy-3-phenylpropan-2-yl}carbamate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 915.7°C at 760 mmHg
• Flash Point: 507.6°C
• Density: 1.102g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl {(1R,2S)-1-[(16S,19R)-15,18-dioxo-16-(propan-2-yl)-2,5,8,11-tetraoxa-14,17,20-triazabicyclo[20.2.2]hexacosa-1(24),22,25-trien-19-yl]-1-hydroxy-3-phenylpropan-2-yl}carbamate

There total 9 articles about tert-butyl {(1R,2S)-1-[(16S,19R)-15,18-dioxo-16-(propan-2-yl)-2,5,8,11-tetraoxa-14,17,20-triazabicyclo[20.2.2]hexacosa-1(24),22,25-trien-19-yl]-1-hydroxy-3-phenylpropan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) → [(1S,2R)-1-Benzyl-2-hydroxy-2-((16S,19R)-16-isopropyl-15,18-dioxo-2,5,8,11-tetraoxa-14,17,20-triaza-bicyclo[20.2.2]hexacosa-1(25),22(26),23-trien-19-yl)-ethyl]-carbamic acid tert-butyl ester (180968-37-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 1-hydroxybenzotriazole, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

3: K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

4: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

5: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

6: ethanol / 24 h / 80 °C

7: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

8: 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / tetrahydrofuran / 120 h / Ambient temperature

With pyridine; lithium hydroxide; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm950641i

Reference yield:

11-amino-3,6,9-trioxaundecanol (86770-74-3) → [(1S,2R)-1-Benzyl-2-hydroxy-2-((16S,19R)-16-isopropyl-15,18-dioxo-2,5,8,11-tetraoxa-14,17,20-triaza-bicyclo[20.2.2]hexacosa-1(25),22(26),23-trien-19-yl)-ethyl]-carbamic acid tert-butyl ester (180968-37-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 1-hydroxybenzotriazole, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

3: K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

4: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

5: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

6: ethanol / 24 h / 80 °C

7: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

8: 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / tetrahydrofuran / 120 h / Ambient temperature

With pyridine; lithium hydroxide; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm950641i

Reference yield:

[(S)-1-(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester (1025893-59-7) → [(1S,2R)-1-Benzyl-2-hydroxy-2-((16S,19R)-16-isopropyl-15,18-dioxo-2,5,8,11-tetraoxa-14,17,20-triaza-bicyclo[20.2.2]hexacosa-1(25),22(26),23-trien-19-yl)-ethyl]-carbamic acid tert-butyl ester (180968-37-0)

Guidance literature:

Multi-step reaction with 7 steps

1: pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

2: K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

3: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

4: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

5: ethanol / 24 h / 80 °C

6: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

7: 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / tetrahydrofuran / 120 h / Ambient temperature

With pyridine; lithium hydroxide; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm950641i

upstream raw materials:

(2R,3R,4S)-2-{4-[2-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

(S)-N-(benzyloxycarbonyl)valine

11-amino-3,6,9-trioxaundecanol

(S)-2-Amino-N-[2-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl]-3-methyl-butyramide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 180968-37-0 tert-butyl {(1R,2S)-1-[(16S,19R)-15,18-dioxo-16-(propan-2-yl)-2,5,8,11-tetraoxa-14,17,20-triazabicyclo[20.2.2]hexacosa-1(24),22,25-trien-19-yl]-1-hydroxy-3-phenylpropan-2-yl}carbamate

Send

Send

Metric Ton KG G Pound L ML

Send

Send