1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: 1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid
• CAS No.: 220239-33-8
• Molecular Formula: C₁₅H₁₂ClNO₃S
• Molecular Weight: 321.784
• Mol file: 220239-33-8.mol

Synonyms:1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid

Chemical Property of 1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid

There total 1 articles about 1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-(4-chloro-phenyl)-5-oxo-3-thiophen-2-yl-pyrrolidine-2,2-dicarboxylic acid diethyl ester → 1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid (220239-33-8)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 5h; Heating;

DOI:10.1016/j.tet.2007.01.058

Reference yield: 79.0%

1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid (220239-33-8) → [1-(4-chlorophenyl)-3-(2-thienyl)-pyrrolidin-2-yl]methanol

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 78 ℃;

DOI:10.1016/j.tet.2007.01.058

Reference yield:

1-(4-chlorophenyl)-5-oxo-3-(2-thienyl)pyrrolidine-2-carboxylic acid (220239-33-8) → N-(4-chlorophenyl)-2-formyl-3-(2-thienyl)pyrrole

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / NaBH₄; iodine / tetrahydrofuran / 78 °C

2: 67 percent / DDQ / benzene / 80 °C

With sodium tetrahydroborate; iodine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; benzene;

DOI:10.1016/j.tet.2007.01.058