Technology Process of (2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-benzylpiperidine
There total 6 articles about (2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-benzylpiperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
indium; ammonium chloride; zinc;
In
ethanol; water;
for 4h;
Reflux;
DOI:10.1021/jo3011914
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2: zinc; indium; ammonium chloride / ethanol; water / 4 h / Reflux
With
indium; ammonium chloride; zinc;
In
tetrahydrofuran; ethanol; water;
DOI:10.1021/jo3011914
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2.1: sodium tetrahydroborate; zinc(II) chloride; triethylamine / tetrahydrofuran / 4 h / 0 - 80 °C / Inert atmosphere
3.1: p-toluenesulfonyl chloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: triethylamine; hydroxylamine hydrochloride / 4 h / Reflux; Inert atmosphere
5.1: manganese(IV) oxide / dichloromethane / 2 h / 0 °C / Inert atmosphere
6.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
7.1: zinc; indium; ammonium chloride / ethanol; water / 4 h / Reflux
With
1H-imidazole; manganese(IV) oxide; indium; sodium tetrahydroborate; hydroxylamine hydrochloride; ammonium chloride; triethylamine; p-toluenesulfonyl chloride; zinc(II) chloride; zinc;
In
tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jo3011914
