4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate

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Chemical Name:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate
CAS No.:1362688-89-8
Molecular Formula:C₃₇H₄₂FN₆O₈P
Molecular Weight:748.748
Hs Code.:

Synonyms:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate

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Chemical Property of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate

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Technology Process of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate

There total 3 articles about 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₅₀FN₆O₁₀P

: 1362688-89-8
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate

Guidance literature:: C₄₂H₅₀FN₆O₁₀P; With phosphoric acid; In chloroform; water; at 20 ℃; for 4.5h;

With water; sodium hydroxide; at 0 - 5 ℃; pH=7;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1362688-89-8
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 1309464-60-5
C₁₈H₁₈BrFO₂

: 221351-21-9
Boc-L-phenylalanine-2-bromoethyl ester

: 1362688-89-8
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

1.2: 40 - 50 °C

1.3: 80 - 100 °C

2.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

2.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; phosphoric acid; In chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013