2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate

Base Information

• Chemical Name: 2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate
• CAS No.: 203932-69-8
• Molecular Formula: C₁₈H₂₃N₄O₈P
• Molecular Weight: 454.376
• Mol file: 203932-69-8.mol

Synonyms:2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate

Chemical Property of 2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate

There total 4 articles about 2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethylphosphonoacetic acid (3095-95-2) → 2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate (203932-69-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / DCC, DMAP, pyridine / CH₂Cl₂ / Ambient temperature

2: 79 percent / (Et₂N)3PN₃Br, t-BuOK / tetrahydrofuran

3: 81 percent / HCl / H₂O / 50 °C

4: 1) N,N-dimethylaniline, 2) Et₃N

With pyridine; hydrogenchloride; dmap; potassium tert-butylate; N,N-dimethyl-aniline; triethylamine; dicyclohexyl-carbodiimide; azidotris(diethylamino)phosphonium bromide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/S0040-4020(97)10435-5

Reference yield:

2-(2-triisopropylsiloxyethoxy)ethyl (diethoxyphosphoryl)acetate (203932-63-2) → 2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate (203932-69-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / (Et₂N)3PN₃Br, t-BuOK / tetrahydrofuran

2: 81 percent / HCl / H₂O / 50 °C

3: 1) N,N-dimethylaniline, 2) Et₃N

With hydrogenchloride; potassium tert-butylate; N,N-dimethyl-aniline; triethylamine; azidotris(diethylamino)phosphonium bromide; In tetrahydrofuran; water;

DOI:10.1016/S0040-4020(97)10435-5

Reference yield:

2-(2-triisopropylsiloxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate (203932-65-4) → 2-(2-phenyldiazoacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate (203932-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / HCl / H₂O / 50 °C

2: 1) N,N-dimethylaniline, 2) Et₃N

With hydrogenchloride; N,N-dimethyl-aniline; triethylamine; In water;

DOI:10.1016/S0040-4020(97)10435-5

upstream raw materials:

phenylglyoxylic acid chloride p-toluenesulfonylhydrazone

2-(2-hydroxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate

diethylphosphonoacetic acid

2-(2-triisopropylsiloxyethoxy)ethyl (diethoxyphosphoryl)acetate

Downstream raw materials:

2-(α-methoxyphenylacetoxyethoxy)ethyl (diethoxyphosphoryl)diazoacetate