C₄₄H₅₈N₈O₁₁S

Base Information

• Chemical Name: C₄₄H₅₈N₈O₁₁S
• CAS No.: 1389332-22-2
• Molecular Formula: C₄₄H₅₈N₈O₁₁S
• Molecular Weight: 907.058
• Mol file: 1389332-22-2.mol

Synonyms:C₄₄H₅₈N₈O₁₁S

Chemical Property of C₄₄H₅₈N₈O₁₁S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₅₈N₈O₁₁S

There total 7 articles about C₄₄H₅₈N₈O₁₁S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C19H25N3O6 (1389331-88-7) + C2HF3O2*C25H35N5O6S → C44H58N8O11S (1389332-22-2)

Guidance literature:

C₁₉H₂₅N₃O₆; With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

C₂HF₃O₂*C₂₅H₃₅N₅O₆S; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201200457

Reference yield:

4-allyl 1-[(2S)-2-(benzylamino)-3-methoxy-3-oxopropyl] N-(tert-butoxycarbonyl)-D-aspartate (1389331-94-5) → C44H58N8O11S (1389332-22-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 18 h / 20 °C / Inert atmosphere

3.1: hydrogen azide; di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane; toluene / 3.5 h / -20 °C / Inert atmosphere

4.1: trimethylphosphane / tetrahydrofuran / 5 h / -20 - 20 °C / Inert atmosphere

5.1: pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 0 - 20 °C / Inert atmosphere

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen azide; 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trimethylphosphane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 3.1: Mitsunobu reaction;

DOI:10.1002/chem.201200457

Reference yield:

C22H29N3O6 (1389331-97-8) → C44H58N8O11S (1389332-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.201200457

upstream raw materials:

C₁₉H₂₅N₃O₆

4-allyl 1-[(2S)-2-(benzylamino)-3-methoxy-3-oxopropyl] N-(tert-butoxycarbonyl)-D-aspartate

C₁₇H₂₀N₂O₅

C₁₇H₁₉N₅O₄