2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester
CAS No.:290308-09-7
Molecular Formula:C₂₀H₃₁FNO₇P
Molecular Weight:447.441
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester

Synonyms:2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester

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Technology Process of 2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester

There total 7 articles about 2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: [(S)-3-tert-Butoxycarbonylamino-4-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-9-yl)-1-fluoro-4-oxo-butyl]-phosphonic acid diethyl ester

: 100-51-6,185532-71-2
benzyl alcohol

: 290308-09-7
2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester

Guidance literature:: With titanium(IV) isopropylate; In toluene; at 120 ℃;
DOI:10.1039/b002188l

Reference yield:

: [(Z)-4-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-9-yl)-1,1-difluoro-4-oxo-but-2-enyl]-phosphonic acid diethyl ester

: 290308-09-7
2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / Me₂Cu(CN)Li₂*2LiBr*2LiCl / diethyl ether; tetrahydrofuran / -78 °C

2.1: 100 percent / H₂ / Pd/C / ethyl acetate

3.1: NaHMDS; 1-chloro-1-nitrosocyclohexane / tetrahydrofuran

3.2: aq. HCl

4.1: Zn; AcOH / tetrahydrofuran

5.1: acetonitrile

6.1: 100 percent / (i-PrO)4Ti / toluene / 120 °C

With titanium(IV) isopropylate; 1-chloro-1-nitrosocyclohexane; Me₂Cu(CN)Li₂*2LiBr*2LiCl; hydrogen; sodium hexamethyldisilazane; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; toluene; acetonitrile; 1.1: Reduction / 2.1: Catalytic hydrogenation / 3.1: Substitution / 3.2: Hydrolysis / 4.1: Reduction / 5.1: Acylation / 6.1: Acylation;
DOI:10.1039/b002188l

Reference yield:

: [(E)-4-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-9-yl)-1-fluoro-4-oxo-but-1-enyl]-phosphonic acid diethyl ester

: 290308-09-7
2-tert-butoxycarbonylamino-4-(diethoxy-phosphoryl)-4-fluoro-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / H₂ / Pd/C / ethyl acetate

2.1: NaHMDS; 1-chloro-1-nitrosocyclohexane / tetrahydrofuran

2.2: aq. HCl

3.1: Zn; AcOH / tetrahydrofuran

4.1: acetonitrile

5.1: 100 percent / (i-PrO)4Ti / toluene / 120 °C

With titanium(IV) isopropylate; 1-chloro-1-nitrosocyclohexane; hydrogen; sodium hexamethyldisilazane; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile; 1.1: Catalytic hydrogenation / 2.1: Substitution / 2.2: Hydrolysis / 3.1: Reduction / 4.1: Acylation / 5.1: Acylation;
DOI:10.1039/b002188l