N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide
• CAS No.: 910896-36-5
• Molecular Formula: C₂₂H₁₉NO₃S
• Molecular Weight: 377.464
• Mol file: 910896-36-5.mol

Synonyms:N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide

Chemical Property of N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide

There total 2 articles about N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-toluenesulfonyl chloride (98-59-9) + 4-methoxy-2-(phenylethynyl)benzeneamine → N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide (910896-36-5)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2018.09.009

Reference yield:

phenylacetylene (536-74-3) → N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide (910896-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2 h / 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane;

DOI:10.1039/c7cc04748g

Reference yield: 99.0%

N-(4-methoxy-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide (910896-36-5) → 5-methoxy-2-phenyl-1-(p-toluenesulfonyl)indole (910896-38-7)

Guidance literature:

With MgAl-layered double hydroxide implanted with Cu₂+; In ethanol; at 80 ℃; for 0.5h; Green chemistry;

DOI:10.1016/j.tetlet.2018.09.009

upstream raw materials:

p-toluenesulfonyl chloride

phenylacetylene

Downstream raw materials:

N-tosyl-5-methoxy-2-phenylindole-3-carboxylic acid

2-(5-methoxy-2-phenyl-1-tosyl-1H-indol-4-yl)-1-(p-tolyl)ethanone

5-methoxy-2-phenyl-1-(p-toluenesulfonyl)indole