2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole

Base Information

• Chemical Name: 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole
• CAS No.: 5998-48-1
• Molecular Formula: C₁₇H₁₆ClNO
• Molecular Weight: 285.773
• Mol file: 5998-48-1.mol

Synonyms:5-chloro-2-benzoxazole

Chemical Property of 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole

Chemical Property:

Purity/Quality:

BENZOXAZOLE, 5-CHLORO-2-[4-(1,1-DIMETHYLETHYL)PHENYL] 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole

There total 4 articles about 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-tert-Butylbenzaldehyde (939-97-9) + 2-hydroxy-5-chloro-aniline (95-85-2) → 5-chloro-2-benzoxazole (5998-48-1)

Guidance literature:

In neat (no solvent); at 140 ℃; for 6h;

DOI:10.1039/c7cy01668a

Reference yield: 90.0%

4-tert-Butylbenzaldehyde (939-97-9) + p-chloro-o-nitrophenol (89-64-5) → 5-chloro-2-benzoxazole (5998-48-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; sulfur; at 130 ℃; for 2h;

DOI:10.1055/s-0039-1690823

Reference yield: 90.0%

4-tert-Butylbenzaldehyde (939-97-9) + 5-chloro-benzoxazole (17200-29-2) → 5-chloro-2-benzoxazole (5998-48-1)

Guidance literature:

With ethylene glycol; zinc(II) chloride; In neat (no solvent); at 120 ℃; for 4h; Green chemistry;

DOI:10.1039/c8ra01094c

upstream raw materials:

4-tert-Butylbenzaldehyde

2-hydroxy-5-chloro-aniline

5-chloro-benzoxazole

p-chloro-o-nitrophenol

Refernces

• 1、 Nguyen, Quang The,Thi Hang, Anh-Hung,Ho Nguyen, Thuy-Linh,Nguyen Chau, Duy-Khiem,Tran, Phuong Hoang. "Phosphonium acidic ionic liquid: An efficient and recyclable homogeneous catalyst for the synthesis of 2-Arylbenzoxazoles, 2-Arylbenzimidazoles, and 2-Arylbenzothiazoles". . p. 11834 - 11842. Retrieved 2018/04/05.
• 2、 Nguyen, Linh H.T.,Nguyen, The T.,Nguyen, Ha L.,Doan, Tan L.H.,Tran, Phuong Hoang. "A new superacid hafnium-based metal-organic framework as a highly active heterogeneous catalyst for the synthesis of benzoxazoles under solvent-free conditions". . p. 4346 - 4350. Retrieved 2017/10/13.