1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide

Base Information

• Chemical Name: 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide
• CAS No.: 1001414-15-8
• Molecular Formula: C₃₃H₂₃BrF₂N₄O₄S
• Molecular Weight: 689.537
• Mol file: 1001414-15-8.mol

Synonyms:1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide

Chemical Property of 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide

There total 7 articles about 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (757978-19-1) + 3-({[1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carbonyl]-amino}-methyl)-phenylboronic acid (1001412-05-0) → 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide (1001414-15-8)

Guidance literature:

With sodium carbonate; triphenylphosphine; palladium diacetate; In water; acetone; at 75 ℃; for 1h; Product distribution / selectivity;

Reference yield:

C15H13F2NO3 (1001412-63-0) → 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide (1001414-15-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / 60 °C

2: pyridine / N,N-dimethyl-formamide

3: sodium carbonate; triphenylphosphine / palladium diacetate / water; acetone / 1 h / 75 °C

With pyridine; sodium hydroxide; water; sodium carbonate; triphenylphosphine; palladium diacetate; In water; N,N-dimethyl-formamide; acetone; 3: Suzuki Coupling;

Reference yield:

1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (1001413-01-9) → 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-(1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamide (1001414-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / N,N-dimethyl-formamide

2: sodium carbonate; triphenylphosphine / palladium diacetate / water; acetone / 1 h / 75 °C

With pyridine; sodium carbonate; triphenylphosphine; palladium diacetate; In water; N,N-dimethyl-formamide; acetone; 2: Suzuki Coupling;

upstream raw materials:

5-bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

3-({[1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carbonyl]-amino}-methyl)-phenylboronic acid

1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

C₁₄H₁₁F₂NO₃