9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine

Base Information

• Chemical Name: 9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine
• CAS No.: 1294503-13-1
• Molecular Formula: C₂₉H₁₅BrF₆N₄
• Molecular Weight: 613.359
• Mol file: 1294503-13-1.mol

Synonyms:9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine

Chemical Property of 9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine

There total 4 articles about 9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-amino-3-(4-bromophenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde (1294502-93-4) + 3,5-bis(trifluoromethyl)phenyl methyl ketone (30071-93-3) → 9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine (1294503-13-1)

Guidance literature:

With potassium hydroxide; In ethanol; Reflux;

DOI:10.1007/s10895-010-0707-0

Reference yield:

ethyl 2-azido-3-(4-bromophenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (958328-75-1) → 9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine (1294503-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 25 °C

2: manganese(IV) oxide / dichloromethane; N,N-dimethyl-formamide / 24 h / 25 °C

3: potassium hydroxide / ethanol / Reflux

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 3: Friedlaender synthesis;

DOI:10.1007/s10895-010-0707-0

Reference yield:

ethyl 4-chloro-3-(4-bromophenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate → 9-(4-bromophenyl)-2-(3,5-di(trifluoromethyl)phenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine (1294503-13-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 3 h / 25 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 25 °C

3: manganese(IV) oxide / dichloromethane; N,N-dimethyl-formamide / 24 h / 25 °C

4: potassium hydroxide / ethanol / Reflux

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium azide; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 4: Friedlaender synthesis;

DOI:10.1007/s10895-010-0707-0

upstream raw materials:

ethyl 2-azido-3-(4-bromophenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

[4-amino-3-(4-bromophenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-yl]methanol

4-amino-3-(4-bromophenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde

3,5-bis(trifluoromethyl)phenyl methyl ketone