(E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

Base Information

Chemical Name:(E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde
CAS No.:1168721-56-9
Molecular Formula:C₂₂H₂₆N₂O₂Si
Molecular Weight:378.546
Hs Code.:

Synonyms:(E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

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Chemical Property of (E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

Chemical Property:

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Technology Process of (E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

There total 3 articles about (E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 1168720-53-3
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

: 1168721-56-9
(E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

Guidance literature:: With N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 20h; Inert atmosphere;

Reference yield:

: 944904-42-1
3-iodo-1H-indazole-6-carbaldehyde

: 1168721-56-9
(E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; water / 3 h / 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 20 h / 100 °C / Inert atmosphere

With tetrabutylammomium bromide; palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; potassium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1021/jm400380m

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1168721-56-9
(E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; water / 3 h / 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 20 h / 100 °C / Inert atmosphere

With tetrabutylammomium bromide; palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; potassium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1021/jm400380m