p-nitrobenzoyl 6α-bromopenicillanate 1-oxide

Base Information

• Chemical Name: p-nitrobenzoyl 6α-bromopenicillanate 1-oxide
• CAS No.: 79634-01-8
• Molecular Formula: C₁₅H₁₅BrN₂O₆S
• Molecular Weight: 431.264
• Mol file: 79634-01-8.mol

Synonyms:p-nitrobenzoyl 6α-bromopenicillanate 1-oxide

Chemical Property of p-nitrobenzoyl 6α-bromopenicillanate 1-oxide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of p-nitrobenzoyl 6α-bromopenicillanate 1-oxide

There total 5 articles about p-nitrobenzoyl 6α-bromopenicillanate 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

6α-bromopenicillan-3α-carboxylic acid-1β-oxide (79703-02-9) + 1-bromomethyl-4-nitro-benzene (100-11-8) → p-nitrobenzoyl 6α-bromopenicillanate 1-oxide (79634-01-8)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 1h;

Reference yield: 77.0%

p-nitrobenzyl 6-bromopenicillanate (100239-31-4) → p-nitrobenzoyl 6α-bromopenicillanate 1-oxide (79634-01-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.166667 - 0.416667h; Product distribution / selectivity;

Reference yield: 70.0%

6α-bromopenicillanic acid 1-oxide potassium salt (79886-08-1) + 1-bromomethyl-4-nitro-benzene (100-11-8) → p-nitrobenzoyl 6α-bromopenicillanate 1-oxide (79634-01-8)

Guidance literature:

In N,N-dimethyl acetamide; at 23 ℃; for 24h;

DOI:10.1021/jm00144a034

upstream raw materials:

6α-bromopenicillanic acid 1-oxide potassium salt

1-bromomethyl-4-nitro-benzene

p-nitrobenzyl 6-bromopenicillanate

6-bromopenicillanic acid

Downstream raw materials:

p-nitrobenzyl 2-<2-oxo-3α-bromo-4-(benzothiazol-2-yldithio)azetidin-1-yl>-2-isopropenylacetate

p-nitrobenzyl 2-[(3S,4R)-3-bromo-4-formylthio-2-oxoazetidin-1-yl]-3-methylbut-2-enoate

2-(2-benzothiazolyldithio)-3-bromo-α-(1-methylethylidene)-4-oxo-1-azetidineacetic acid β-nitrobenzyl ester

p-nitrobenzyl 6α-bromo-2β-<<(4-nitrobenzoyl)oxy>methyl>-2α-methylpenam-3α-carboxylate 1,1-dioxide