(1'S,2'S)-1-(3-furyl)-2-(2'-hydroxy-2',6',6'-trimethylcyclohexyl)-1-ethanone

Base Information

• Chemical Name: (1'S,2'S)-1-(3-furyl)-2-(2'-hydroxy-2',6',6'-trimethylcyclohexyl)-1-ethanone
• CAS No.: 124263-08-7
• Molecular Formula: C₁₅H₂₂O₃
• Molecular Weight: 250.338
• Mol file: 124263-08-7.mol

Synonyms:(1'S,2'S)-1-(3-furyl)-2-(2'-hydroxy-2',6',6'-trimethylcyclohexyl)-1-ethanone

Chemical Property of (1'S,2'S)-1-(3-furyl)-2-(2'-hydroxy-2',6',6'-trimethylcyclohexyl)-1-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S,2'S)-1-(3-furyl)-2-(2'-hydroxy-2',6',6'-trimethylcyclohexyl)-1-ethanone

There total 27 articles about (1'S,2'S)-1-(3-furyl)-2-(2'-hydroxy-2',6',6'-trimethylcyclohexyl)-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(+/-)-(1'SR,2'SR)-α-<(2'-hydroxy-2',6',6'-trimethylcyclohexyl)methyl>furan-3-methanol (69924-97-6,69979-79-9,69979-80-2,69979-81-3,124263-10-1,124263-11-2,124263-12-3) → (+/-)-1-(3-furyl)-(2α-hydroxy-2,6,6-trimethylcyclohexyl)ethanone (90987-31-8,124263-08-7,124263-09-8)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1039/P19850002463

Reference yield: 60.0%

3-furyllithium (53101-93-2) + (+/-)-(3aα,7aβ)-4,4-7a-trimethyl-3a,4,5,6,7,7a-hexahydrobenzofuran-2(3H)-one (37531-07-0,16778-27-1,19432-10-1,24739-75-1,37531-06-9,71075-17-7,104527-56-2,104640-83-7,104641-34-1) → (+/-)-1-(3-furyl)-(2α-hydroxy-2,6,6-trimethylcyclohexyl)ethanone (90987-31-8,124263-08-7,124263-09-8)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1039/c39840000074

Reference yield: 56.0%

((1S,2S)-2-methoxymethoxy-2,6,6-trimethyl-cyclohexyl)-acetonitrile (868048-09-3) + 3-bromofurane (22037-28-1) → (1'S,2'S)-1-(3-furyl)-2-(2'-hydroxy-2',6',6'-trimethylcyclohexyl)-1-ethanone (124263-08-7)

Guidance literature:

3-bromofurane; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1.5h;

((1S,2S)-2-methoxymethoxy-2,6,6-trimethyl-cyclohexyl)-acetonitrile; In diethyl ether; hexane; at -45 ℃; for 15h;

With hydrogenchloride; In methanol; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2005.07.087

upstream raw materials:

3-bromofurane

(-)-trans-tetrahydroactinidiolide

((1S,2S)-2-methoxymethoxy-2,6,6-trimethyl-cyclohexyl)-acetonitrile

(1S,2S,5S)-2-hydroxy-2,8,8-trimethyl-6-oxabicyclo[3.2.1]octan-7-one

Downstream raw materials:

(1S,1'S,2'S)-1-(3-furyl)-2-(2-'hydroxy-2',6',6'-trimethylcyclohexyl)ethanol

(+/-)-(αRS,1'SR,2'SR)-α-<(2'-hydroxy-2',6',6'-trimethylcyclohexyl)methyl>furan-3-methanol

(+/-)-(αRS,1'RS,2'RS)-α-<(2'-hydroxy-2',6',6'-trimethylcyclohexyl)methyl>furan-3-methanol