Toluene-4-sulfonic acid 3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid 3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl ester
CAS No.:135027-61-1
Molecular Formula:C₁₅H₂₂O₅S
Molecular Weight:314.403
Hs Code.:

Synonyms:Toluene-4-sulfonic acid 3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Toluene-4-sulfonic acid 3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl ester

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Technology Process of Toluene-4-sulfonic acid 3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl ester

There total 10 articles about Toluene-4-sulfonic acid 3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 51268-87-2
(4S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 135027-61-1
Toluene-4-sulfonic acid 3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 12h;
DOI:10.1021/jo0507993

Reference yield: 85.0%

: 6318-30-5
2,2-dimethyl-4-(3-hydroxypropyl)-1,3-dioxolane

: 98-59-9
p-toluenesulfonyl chloride

: 69380-64-9,87046-17-1,135027-61-1,135358-19-9
rac-2,2-dimethyl-4-(3'-hydroxypropyl)-1,3-dioxolan toluene-p-sulphonate

Guidance literature:: With pyridine; 1.) 0 deg C, 2 h, 2.) -20 deg C, overnight;
DOI:10.1021/jo00381a021

Reference yield:

: 64520-58-7,917877-01-1
ethyl (E)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate

: 135027-61-1
Toluene-4-sulfonic acid 3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / Pd(OH)2/C / methanol / 2 h

2: 15.6 g / LAH / diethyl ether / 1 h / 0 °C

3: 99 percent / triethylamine / CH₂Cl₂ / 12 h / 0 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium dihydroxide; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo0507993