2-(3-chloro-1-benzothien-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(3-chloro-1-benzothien-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole
• CAS No.: 333397-35-6
• Molecular Formula: C₁₇H₁₁ClN₂O₂S
• Molecular Weight: 342.806

Synonyms:2-(3-chloro-1-benzo[b]thiophen-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

Chemical Property of 2-(3-chloro-1-benzothien-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

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Technology Process of 2-(3-chloro-1-benzothien-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

There total 4 articles about 2-(3-chloro-1-benzothien-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C17H13ClN2O2S (346718-75-0) → 2-(3-chloro-1-benzo[b]thiophen-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole (333397-35-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2009.02.054

Reference yield:

Cinnamic acid (621-82-9) → 2-(3-chloro-1-benzo[b]thiophen-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole (333397-35-6)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride; chlorobenzene

2: hydrazine hydrate / ethanol / 4 h / Reflux

3: 1,4-dioxane / Reflux

4: chloroamine-T / ethanol / Microwave irradiation

With thionyl chloride; chloroamine-T; hydrazine hydrate; chlorobenzene; In 1,4-dioxane; ethanol;

Reference yield:

3-chlorobenzo[b]thiophen-2-carbonyl chloride (21815-91-8) → 2-(3-chloro-1-benzo[b]thiophen-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole (333397-35-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 4 h / Reflux

2: 1,4-dioxane / Reflux

3: chloroamine-T / ethanol / Microwave irradiation

With chloroamine-T; hydrazine hydrate; In 1,4-dioxane; ethanol;

upstream raw materials:

C₁₇H₁₃ClN₂O₂S

3-chlorobenzo[b]thiophen-2-carbonyl chloride

Cinnamic acid

3-chloro-2-hydrazinocarbonylbenzothiophene

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