Technology Process of 5-(tert-butyl)-3-phenyl-4,5-dihydroisoxazole
There total 5 articles about 5-(tert-butyl)-3-phenyl-4,5-dihydroisoxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 4h;
Molecular sieve;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b01401
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 70 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Molecular sieve; Inert atmosphere
With
tetrabutyl ammonium fluoride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.7b01401
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
2.1: hydrazine hydrate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 10 h / 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 70 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Molecular sieve; Inert atmosphere
With
di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrazine hydrate; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.7b01401
