trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one

Base Information

Chemical Name:trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one
CAS No.:745074-70-8
Molecular Formula:C₂₉H₃₉N₃O₃
Molecular Weight:477.647
Hs Code.:

Synonyms:trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one

Suppliers and Price of trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one

There total 3 articles about trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 71922-59-3
N-benzyl-N-benzyloxycarbonyl-glycine

: 745074-65-1
(2R,5R)-1-(hexylideneamino)-2,5-dimethylpyrrolidine

: 745074-70-8
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one

Guidance literature:: With N-methyl-2-methylpyridinium iodide; N-ethyl-N,N-diisopropylamine; In toluene; at 80 ℃; for 10h; diastereospecific reaction; Inert atmosphere;
DOI:10.1002/ejoc.200800194

Reference yield:

: 34338-96-0
(2S,5S)-2,5-hexanediol

: 745074-70-8
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂ / 3 h / 0 °C

2.1: hydrazine monohydrate / 20 °C

2.2: 1.32 g / diethyl ether

3.1: i-Pr₂NEt; 2-chloro-N-methylpyridinium iodide / toluene / 10 h / 80 °C

With 2-chloro-1-methyl-pyridinium iodide; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/ol0490328

Reference yield:

: 119008-52-5
(S,S)-2,5-bis(methylsulfonyloxy)hexane

: 745074-70-8
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-pentylazetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine monohydrate / 20 °C

1.2: 1.32 g / diethyl ether

2.1: i-Pr₂NEt; 2-chloro-N-methylpyridinium iodide / toluene / 10 h / 80 °C

With 2-chloro-1-methyl-pyridinium iodide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In toluene;
DOI:10.1021/ol0490328