5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

Base Information

Chemical Name:5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid
CAS No.:1373274-54-4
Molecular Formula:C₂₂H₁₉FN₄O₃
Molecular Weight:406.416
Hs Code.:

Synonyms:5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

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Chemical Property of 5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

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Technology Process of 5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

There total 6 articles about 5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1373278-08-0
methyl 5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373274-54-4
5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.416667h;

Reference yield:

: 20776-50-5
2-amino-4-bromobenzoic acid

: 1373274-54-4
5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 40 °C

2: acetic anhydride / 5 h / 150 °C

3: acetic acid / 1 h / 100 °C

4: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 0.5 h / 120 °C / microwave irradiation; Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran / 0.42 h / 20 °C

With water; acetic anhydride; potassium carbonate; acetic acid; triethylamine; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 35444-44-1
methyl adipoyl chloride

: 1373274-54-4
5-(3-(4-fluorophenyl)-4-oxo-7-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 40 °C

2: acetic anhydride / 5 h / 150 °C

3: acetic acid / 1 h / 100 °C

4: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 0.5 h / 120 °C / microwave irradiation; Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran / 0.42 h / 20 °C

With water; acetic anhydride; potassium carbonate; acetic acid; triethylamine; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water;