Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

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Chemical Name:Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester
CAS No.:90742-28-2
Molecular Formula:C₃₄H₃₆N₃O₉PS₂
Molecular Weight:725.78
Hs Code.:

Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Synonyms:Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

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Chemical Property of Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

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Technology Process of Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

There total 7 articles about Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 90335-48-1
S,S-diphenyl 2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine-3'-phosphorodithioate

: 90742-28-2
Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Guidance literature:: With trifluoroacetic acid; In chloroform; at 0 ℃; for 0.333333h;
DOI:10.1021/ja00328a042

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 90742-28-2
Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: TFA / dioxane / 11 h

2: pyridine / 0.58 h / 0 °C

3: Et₄NBr, KF, H₂O / acetonitrile / 0.5 h / 96 °C

4: 96 percent / pyridine / 0.67 h

5: 78 percent / pyridine, MDS / 2.5 h

6: 88 percent / 0.5percent TFA / CHCl₃ / 0.33 h / 0 °C

With pyridine; potassium fluoride; tetraethylammonium bromide; water; trifluoroacetic acid; In 1,4-dioxane; pyridine; chloroform; acetonitrile;
DOI:10.1021/ja00328a042

Reference yield:

: 90742-20-4
2'-O-tetrahydropyranyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

: 90742-28-2
Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 0.58 h / 0 °C

2: Et₄NBr, KF, H₂O / acetonitrile / 0.5 h / 96 °C

3: 96 percent / pyridine / 0.67 h

4: 78 percent / pyridine, MDS / 2.5 h

5: 88 percent / 0.5percent TFA / CHCl₃ / 0.33 h / 0 °C

With pyridine; potassium fluoride; tetraethylammonium bromide; water; trifluoroacetic acid; In pyridine; chloroform; acetonitrile;
DOI:10.1021/ja00328a042