(R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride

Base Information

• Chemical Name: (R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride
• CAS No.: 1093076-74-4
• Molecular Formula: C₂₅H₃₁N₃O₄S*ClH
• Molecular Weight: 506.066
• Mol file: 1093076-74-4.mol

Synonyms:(R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride

Chemical Property of (R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride

There total 1 articles about (R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-(tert-butoxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (819805-78-2) → (R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride (1093076-74-4)

Guidance literature:

With hydrogenchloride; methoxybenzene; In 1,4-dioxane; at 20 ℃; for 1.5h;

DOI:10.1016/j.bmc.2008.10.011

Reference yield: 100.0%

(R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride (1093076-74-4) + (S)-2-tert-butoxycarbonylamino-2-((R)-tetrahydrofuran-3-yl)acetic acid → (R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-((S)-2-(tert-butoxycarbonyl)amino-2-((R)-tetrahydrofuran-3-yl)acetyl)amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

DOI:10.1021/acs.jmedchem.7b01709

Reference yield: 72.0%

(R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride (1093076-74-4) + o-methylphenoxyacetic acid (1878-49-5) → KNI-10079 (820220-83-5)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

DOI:10.1016/j.bmc.2008.10.011

upstream raw materials:

(R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-(tert-butoxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Downstream raw materials:

KNI-10088

KNI-10087

KNI-10092

KNI-10094